When his divorce proceedings began, Anthony was spotted with long-time friend Jennifer Lopez. Prior to his first marriage and her second, they had briefly dated. Lopez and Anthony recorded a duet in 2004, for Lopez's film Shall We Dance? Lopez and Anthony married on June 5, 2004, less than a week after his divorce was finalized on June 1. Guests had been invited to an "afternoon party", unaware they were attending a wedding. In February 2005, Lopez said about the marriage, "Everyone knows. It's not a secret." Months later, Anthony's daughter, Arianna, appeared Lopez's "Get Right".
On November 8, 2007, Anthony and Lopez confirmed to fans in a Miami concert that Lopez was pregnant. Twins Emme Maribel Muñiz and Maximillian David Muñiz were born February 22, 2008. People paid $6 million for the first photos of the twins.
In 2009, Anthony and Lopez purchased a stake in the Miami Dolphins. They joined several personalities in buying small stakes in the club, including Gloria and Emilio Estefan and Venus and Serena Williams.
J-Lo with Her Twins Baby